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Science

2023

14th Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment (NCHIV)

Exploring and comparing Biomarker Profiles and Comorbidity burden in people with and without HIV: A Latent Profile Analysis of the AGEhIV Cohort Study
Presented by: Manon Vanbellinghen

The Dutch Association of HIV-treating physicians (NVHB), winter meeting

Similar cellular immune responses after SARS-CoV-2 vaccination in older people with well-controlled HIV and demographically and lifestyle-comparable controls without HIV
Presented by: Myrthe Verburgh

2022

HIV Glasgow

Older people with well-controlled HIV have similar antibody and higher T-cell responses after vaccination against SARS-CoV-2 compared to demographically and lifestyle-comparable controls without HIV
Presented by: Myrthe Verburgh

2021

14th Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment (NCHIV)

People with HIV and suppressed viremia on ART are not at increased risk for acquiring SARS-CoV-2 infection
Presented by: Myrthe Verburgh

2020

13th Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment (NCHIV)

Faster decline in lung function in treated HIV-positive vs. HIV-negative AGEhIV cohort participants independent of smoking behavior
Presented by: Sebastiaan Verboeket

22nd International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Faster decline in lung function in treated HIV-positive vs. HIV-negative AGEhIV cohort participants independent of smoking behavior
Presented by: Sebastiaan Verboeket

Selective drop-out of HIV-positive AGEhIV Cohort participants may bias estimates of long-term adverse health effects of ageing with HIV
Presented by: Eveline Verheij

2019

International Workshop on HIV Observational Databases (IWHOD)

Development and validation of an index to assess the comorbidity burden of people living with HIV
Presented by: Davide de Francesco

Conference on Retroviruses and Opportunistic Infections (CROI)

Impact and determinants of comorbidity clusters in people living with HIV
Presented by: Davide de Francesco

The Dutch Association of HIV-treating physicians (NVHB), mid-summer meeting

Switchen naar een antiretroviraal regime met een integraseremmer in het AGEhIV Cohort is niet geassocieerd met een bovengemiddelde toename in lichaamsgewicht
Presented by: Sebastiaan Verboeket

21st International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Colonic microbiota exhibits disparate associations with HIV-infection and sexual practices
Presented by: Eveline Verheij

Switching to an integrase inhibitor containing antiretroviral regimen is not associated with above-average weight gain in middle-aged people living with HIV on long-term suppressive antiretroviral therapy, the AGEhIV cohort study
Presented by: Sebastiaan Verboeket

Development and validation of an index to assess the comorbidity burden of people living with HIV
Presented by: Davide De Francesco

17th European AIDS Conference (EACS)

Colonic microbiota exhibits disparate associations with HIV-infection and sexual practices
Presented by: Eveline Verheij

Switching to an integrase inhibitor containing antiretroviral regimen is not associated with above-average weight gain in middle-aged people living with HIV on long-term suppressive antiretroviral therapy, the AGEhIV cohort study
Presented by: Sebastiaan Verboeket

Development and validation of an index to assess the comorbidity burden of people living with HIV
Presented by: Davide De Francesco

2018

International Workshop on HIV Observational Databases (IWHOD)

Pulmonary function in controlled HIV-infection: lower forced vital capacity but similar 1-second forced expiratory volume among those with limited smoking experience
Presented by: Sebastiaan Verboeket

International Symposium on HIV and Emerging Infectious Diseases (ISHEID)

Dealing with multimorbidities in HIV
Presented by: Rosan van Zoest

International AIDS Conference

Heterogeneity in pulmonary function indices by HIV status and cumulative smoking intensity among well-controlled HIV-infected persons compared to HIV-uninfected participants in the AGEhIV cohort
Presented by: Sebastiaan Verboeket

Link

Increased risk of both mortality and incident comorbidity among frail HIV-positive and HIV-negative participants in the AGEhIV cohort study, and increased risk of frailty progression in those with HIV
Presented by: Eveline Verheij

Link

Congrès VIH Complications et Comorbidités

AGEhIV cohort update
Presented by: Rosan van Zoest

International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

HIV-negative men who have sex with men have lower CD4 to CD8 ratios driven by higher absolute CD8 T-lymphocyte counts compared to HIV-negative heterosexual men
Presented by: Sebastiaan Verboeket

Link

2017

16th European AIDS Conference

HIV and Ageing: Using Cohort Data to Separate the Myths from Reality
Presented by: Rosan van Zoest

Link

19th Bangkok International Symposium on HIV Medicine

Co- and multi-morbidity in people ageing with HIV
Presented by: Peter Reiss

Link

Conference on Retroviruses and Opportunistic Infections (CROI)

Longitudinal analysis shows no evidence for accelerated brain ageing in treated HIV
Presented by: Rosan van Zoest

Link

The Dutch Association of HIV-treating physicians (NVHB), winter meeting

Brain grey and white matter (micro)structural abnormalities in successfully treated HIV infection most likely reflect historical injury
Presented by: Rosan van Zoest

Hiv-infectie is onafhankelijk geassocieerd met verminderde erectiele functie onder mannen van middelbare leeftijd die seks hebben met mannen
Presented by: Maartje Dijkstra

International Workshop on HIV Observational Databases (IWHOD)

HIV-1 status is independently associated with decreased erectile function among middle-aged men who have sex with men
Presented by: Maartje Dijkstra

Link

WEON

HIV-1 status is independently associated with decreased erectile function among middle-aged men who have sex with men
Presented by: Maartje Dijkstra

Link

International AIDS Society Conference

HIV-1 status is independently associated with decreased erectile function among middle-aged men who have sex with men
Presented by: Maartje Dijkstra

Link

People living with HIV and HIV-negative individuals with similar lifestyles show greater age advancement compared to healthy blood donors
Presented by: Davide de Francesco

Link

2016

International Workshop on HIV Observational Databases

HIV infection is independently associated with chronic kidney disease and mild glomerular hyperfiltration, particularly in those of African descent
Presented by: Katherine Kooij

Primary and secondary cardiovascular prevention is suboptimal in both HIV-infected and HIV-uninfected participants of the AGEhIV Cohort Study
Presented by: Rosan van Zoest

The Dutch Association of HIV-treating physicians (NVHB), summer meeting

Primary and secondary cardiovascular prevention is suboptimal in both HIV-infected and HIV-uninfected participants of the AGEhIV Cohort Study
Presented by: Rosan van Zoest

International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Primary and secondary cardiovascular prevention is suboptimal in both HIV-infected and HIV-uninfected participants of the AGEhIV Cohort Study
Presented by: Rosan van Zoest
Link

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

HIV infection is independently associated with chronic kidney disease and mild glomerular hyperfiltration, particularly in those of African descent
Presented by: Katherine Kooij
Link

Prise en charge clinique du sujet âgé vivant avec le VIH, Marseille

Elderly & HIV: Results from the AGEhIV Cohort Study 
Presented by: Rosan van Zoest

European HIV Nursing Conference

The impact of the number of co-morbidities and aging on Health Related Quality of Life in HIV-infected and uninfected individuals
Presented by: Nienke Langebeek

2015

The Dutch Association of HIV-treating physicians (NVHB), winter meeting

Performance of 4 Tools to Screen for HIV-Associated Cognitive Impairment.
Presented by: Rosan van Zoest

Highlights in Basic and Clinical Science (HIBIC) conference

Low BMD in patients with well-suppressed HIV infection.
Presented by: Katherine Kooij

Conference on Retroviruses and Opportunistic Infections

Performance of 4 Tools to Screen for HIV-Associated Cognitive Impairment.
Presented by: Rosan van Zoest
Link

APRI and FIB4: Associated With D-Drug Exposure, Low CD4 Count and Monocyte Activation
Presented by: Katherine Kooij
Link

International Workshop on HIV Observational Databases

Frailty predicts all-cause mortality, hospital admission and falls in HIV-infected and -uninfected middle-aged individuals
Presented by: Katherine Kooij/Ferdinand Wit

Higher prevalence of hypertension in HIV-infected individuals partially explained by increased waist-hip ration rather than BMI, other traditional risk factors or markers of systemic inflammation
Presented by: Rosan van Zoest

Nederlands Oogheelkundig Gezelschap (NOG)

Structureel en functioneel oogheelkundig onderzoek bij HIV-positieve patienten
Presented by: Nazli Demirkaya

Association for Research in Visual Science and Opthalmology (ARVO)

Visual function and corneal endothelium analysis in patients with well-suppressed HIV infection
Presented by: Nazli Demirkaya

The Dutch Association of HIV-treating physicians (NVHB) summer meeting

Hogere prevalentie van hypertensie onder hiv-geïinfecteerden grotendeels verklaard door abdominale obesitas en stavudine-gerelateerde lipoatrofie
Presented by: Rosan van Zoest

European AIDS Clinical Society

Increased prevalence of hypertension in HIV-infected patients, most with suppressed viraemia on combination antiretroviral therapy, is associated with changes in body composition
Presented by: Rosan van Zoest
Link

Frailty predicts all-cause mortality, hospital admission and falls in HIV-infected and uninfected middle-aged individuals
Presented by: Katherine Kooij
Link

MAPPING Workshop MICCAI

A neuroscience gateway for handling and processing population imaging studies
Presented by: Matthan Caan
Link

Assessment of Resources and Opportunities for NeuroAIDS Research

Prevalence of NCI in the Netherlands
Presented by: Judith Schouten
Link

3e Landelijk Valsymposium

Frailty voorspelt mortaliteit, ziekenhuisopname en vallen in hiv-geïnfecteerde en ongeïnfecteerde mensen van middelbare leeftijd
Presented by: Katherine Kooij
Link

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

The impact of the number of comorbidities and aging on Health Related Quality of Life in HIV-infected and uninfected individuals
Presented by: Nienke Langebeek
Link

VII Congreso Nacional GeSIDA

HIV, Co-morbidity and Ageing
Presented by: Peter Reiss
Link

2014

Conference on Retroviruses and Opportunistic Infections (CROI)

Multivariate normative comparison, a novel method for more reliably detecting cognitive impairment in HIV infection. 
Presented by: Judith Schouten

ISMRM Benelux Chapter

White Matter Abnormalities in Males with Suppressed HIV-infectiono n cART compared to representative controls.
Presented by: Tanja Su

International Workshop on HIV Observational Databases

HIV infection is independently associated with frailty in middle aged HIV infected individuals compared to uninfected controls
Presented by: Katherine Kooij

Dutch Ophthalmic Society Conference

Neuroretinal degeneration in HIV-positive patients
Presented by: Nazli Demirkaya

Innsbruck HIV Update

Comorbidity and ageing in HIV-1 infection: The AGEhIV Cohort Study
Presented by: Peter Reiss

HIV Drug Therapies in the Americas

Co-morbidities and Ageing in HIV
Presented by: Peter Reiss

Association for Research in Visual Science and Opthalmology

Neuroretinal degeneration in HIV-positive patients
Presented by: Nazli Demirkaya

Joint Annual Meeting ISMRM-ESMRMB

White Matter Abnormalities in Males with Suppressed HIV-infectiono n cART compared to representative controls
Presented by: Tanja Su

WEON

Prevalence and determinants of insufficient work ability in older HIV-positive and HIV-negative workers
Presented by: Lisanne Moller

International Symposium on Neurobiology and Neuroendocrinology of Aging

Multivariate normative comparison, a novel method for more reliably detecting cognitive impairment in HIV infection
Presented by: Judith Schouten

HIV infection is independently associated with frailty in middle aged HIV infected individuals compared to uninfected controls
Presented by: Katherine Kooij

White Matter Abnormalities in Adequately treated HIV-infection 
Presented by: Tanja Su

Immune activation and immunosenescence in HIV infection.
Presented by: Neeltje Kootstra

International AIDS Conference

Prevalence and determinants of insufficient work ability in older HIV-positive and HIV-negative workers
Presented by: Ronald Brands

Disentangling Biological Aging, the Inflammatory Effects of Long Term  HIV infection and Adverse Effects of ART 
Presented by: Peter Reiss

International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Higher prevalence of hypertension in HIV-infected patients partially explained by increased waist-hip ratio rather than BMI, other traditional risk factors or markers of systemic inflammation.
Presented by: Rosan van Zoest

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

HIV infection is independently associated with frailty in middle-aged HIV-infected individuals compared to uninfected controls.
Presented by: Katherine Kooij

Higher prevalence of hypertension in HIV-infected individuals partially explained by increased waist-hip ratio rather than BMI, other traditional risk factors or markers of systemic inflammation.
Presented by: Rosan van Zoest

Accentuated CD8+ T-cell senescence is associated with both age and CD8+ T cell activation in long-term treated HIV-1 infected patients.
Presented by: Viviana Cobos Jiménez

Prevalence and determinants of insufficient work ability in older HIV-positive and HIV-negative workers.
Presented by: Lisanne Moller

2013

International Workshop on HIV Observational Databases

Prevalence and determinants of reduced bone mineral density in ageing HIV-1-positive and HIV-negative individuals.
Presented by: Katherine Kooij

The Dutch Association of HIV-treating physicians (NVHB), spring meeting

Prevalence and determinants of reduced bone mineral density in ageing HIV-1-positive and HIV-negative individuals.
Presented by: Katherine Kooij

International Neuropsychological Society Mid-Year Meeting

Neuropsychological and Neuroimaging Status of Middle-aged HIV-infected Males with Suppressed Infection on cART Compared to a Respresentative Control Group.
Presented by: Tanja Su

AIDS Impact Conference

Prevalence and determinants of non-participation in paid work among ageing HIV-1 infected and HIV-uninfected individuals.
Presented by: Ineke Stolte

European AIDS Clinical Society (EACS) Conference

Prevalence and determinants of reduced bone mineral density in ageing HIV-1-positive and HIV-negative individuals.
Presented by: Katherine Kooij

Greater arterial stiffness in middle-aged HIV-1-positive individuals largely explained by higher prevalence of hypertension and smoking.
Presented by: Katherine Kooij

International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Prevalence and determinants of reduced bone mineral density in ageing HIV-1-positive and HIV-negative individuals.
Presented by: Katherine Kooij

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

Calendar age predicts CD8+ T-cell senescence in long-term treated HIV-infected patients but not in HIV-uninfected controls.
Presented by: Maaike Joerink

Najaarsvergadering NVVI

Calendar age predicts CD8+ T-cell senescence in long-term treated HIV-infected patients but not in HIV-uninfected controls.
Presented by: Maaike Joerink

Annual meeting of the Netherlands Ophthalmological Society (NOG)

Baseline ophthalmological results substudy AGEhIV.
Presented by: Nazli Demirkaya

Annual meeting of the Association for Research in Vision and Opthalmology (ARVO)

Baseline ophthalmological results substudy AGEhIV.
Presented by: Nazli Demirkaya

2012

International Workshop on HIV Observational Databases

Comorbidity and ageing with HIV A prospective comparative cohort study.
Presented by: Judith Schouten

International Workshop on Co-morbidities and Adverse Drug Reactions in HIV

Comorbidity and ageing with HIV A prospective comparative cohort study.
Presented by: Judith Schouten

International AIDS Conference (IAS)

Comorbidity and ageing with HIV A prospective comparative cohort study.
Presented by: Judith Schouten

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

Prevalence and determinants of unemployment among ageing HIV-1 infected and HIV-uninfected individuals.
Presented by: Ineke Stolte

International Congress on Drug Therapy in HIV

Prevalence and determinants of unemployment among ageing HIV-1 infected and HIV-uninfected individuals.
Presented by: Ineke Stolte

2011

Netherlands Conference on HIV Pathogenesis, Epidemiology, Prevention and Treatment

Comorbidity and ageing with HIV A prospective comparative cohort study.
Presented by: Judith Schouten

2023

No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands.
Verburgh ML, Van der Valk M, Rijnders BJA, Reiss P, Wit FWNM
AIDS. 2023 Jul 15;37(9):1481-1486
Link

Robust Vaccine-Induced as Well as Hybrid B- and T-Cell Immunity across SARS-CoV-2 Vaccine Platforms in People with HIV
Verburgh ML*, Van Pul L*, Grobben M*,  Boyd A, Wit FWNM, Van Nuenen AC, Van Dort KA, Tejjani K, Van Rijswijk J, Bakker M, Van der Hoek L, Schim van der Loeff MF, Van der Valk M, Van Gils MJ*, Kootstra NA*, Reiss P*; for the AGEhIV Study Group.* Authors contributed equally
Microbiol Spectr. 2023 Jun 15;11(3):e0115523.
Link

Long-term evolution of comorbidities and their disease burden in individuals with and without HIV as they age: analysis of the prospective AGEhIV cohort study.
Verheij E, Boyd A, Wit FW, Verboeket SO, Verburgh ML, Van der Valk M, Schim van der Loeff MF, Reiss P; on behalf of the AGEhIV cohort study
Lancet HIV. 2023 Mar;10(3):e164-e174.
Link

2022

Change in Substance Use and the Effects of Social Distancing on Health-Related Quality of Life and Depressive Symptoms During the COVID-19 Pandemic in People Living With and Without HIV
Schaaf, Reja E. A.; Verburgh, Myrthe L.; Boyd, Anders; Wit, Ferdinand W.; Nieuwkerk, Pythia T.; Schim van der Loeff, Maarten F.; Reiss, Peter;  for the AGEhIV Study Group.
JAIDS Journal of Acquired Immune Deficiency Syndromes. 2022, 91(3):p 261-268
Link

The experienced positive and negative influence of HIV on quality of life of people with HIV and vulnerable to HIV in the Netherlands
Romijnders KAGJ, de Groot L, Vervoort SCJM, Basten M, van Welzen BJ, Kretzschmar ME, Reiss P, Davidovich U, van der Loeff MFS, Rozhnova G.
Sci Rep. 2022 Dec 19;12(1):21887
Link

2021

Similar risk of SARS-CoV-2 infection and similar nucleocapsid antibody levels in people with well-controlled HIV and a comparable cohort of people without HIV
Myrthe L. Verburgh, Anders Boyd, Ferdinand W.N.M. Wit, Maarten F. Schim van der Loeff, Marc van der Valk, Margreet Bakker, Neeltje A. Kootstra, Lia van der Hoek and Peter Reiss; on behalf of the AGEhIV Cohort Study Group.
J Infect Dis. 2021; online ahead of print.
Link

The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities
Vujkovic-Cvijin I, Sortino O, Verheij E, Wit FW, Kootstra NA, Sellers B, Schim van der Loeff M, Belkaid Y, Reiss P, Sereti I.
J Infect Dis. 2021; 224(8): 1405-1409
Link

Generally rare but occasionally severe weight gain after switching to an integrase inhibitor in virally suppressed AGEhIV cohort participants
Sebastiaan O. Verboeket, Anders Boyd, Ferdinand W. Wit, Eveline Verheij, Maarten F. Schim van der Loeff, Neeltje Kootstra, Marc van der Valk, Peter Reiss, on behalf of the AGEhIV Cohort Study Group.
PLoS One. 2021; 16(5): e0251205.
Link

Changes in lung function among treated HIV-positive and HIV-negative individuals: analysis of the prospective AGEhIV cohort study
Sebastiaan O. Verboeket, Anders Boyd, Ferdinand W. Wit, Eveline Verheij, Maarten F. Schim van der Loeff, Neeltje Kootstra, Marc van der Valk, Reindert P. van Steenwijk, Bradley Drummond, Gregory D. Kirk, Peter Reiss; on behalf of the AGEhIV Cohort Study.
Lancet Healthy Longev. 2021; 2: e202-11.

Link

2020

Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men
Sebastiaan O. Verboeket, Ferdinand W. Wit, Eveline Verheij, Rosan A. van Zoest, Neeltje A. Kootstra, Marc van der Valk, Jan M. Prins, Maarten F. Schim van der Loeff, and Peter Reiss; on behalf of the AGEhIV Study Group.
J Infect Dis 2020 Jan 31;jiaa048.
Link

Frailty is associated with mortality and incident comorbidity among middle-aged HIV-positive and HIV-negative participants
Verheij. E, Kirk. GD, Wit. FW, van Zoest. RA, Verboeket. SO, Lemkes. BA, Schim van der Loeff. MF, Reiss. P, for the AGEhIV Cohort
J Infect Dis 2020 Aug 17;222(6):919-928.
Link

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases
I. Vujkovic-Cvijin, O. Sortino, E. Verheij, J. Sklar, F. W. Wit, N. A. Kootstra, B. Sellers, J. M. Brenchley, J. Ananworanich, M. Schim van der Loeff, Y. Belkaid, P. Reiss & I. Sereti
Nature Communications 2020 May 15;11(1):2448.
Link

Frequency, risk factors and mediators of frailty transitions during long-term follow-up among people with HIV and HIV-negative AGEhIV Cohort participants
Verheij. E, Wit. FW, Verboeket. SO, Schim van der Loeff. MF, Nellen. JF, Reiss. P, Kirk. GD
J Acquir Immune Defic Syndr 2020 Jan 1;86(1):110-118.
Link

2019

Reduced Forced Vital Capacity among HIV-infected middle-aged individuals
Verboeket SO, Wit FW, Kirk GD, Drummond MB, van Steenwijk RP, van Zoest RA, Nellen JF, van der Loeff MFS, Reiss P.
J Infect Dis 2019 Apr 8;219(8):1274-1284.
Link

Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment
Underwood J, De Francesco D, Cole JH, Caan MWA, van Zoest RA, Schmand BA, Sharp DJ, Sabin CA, Reiss P, Winston A; COmorBidity in Relation to AIDS (COBRA) Collaboration and the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) Study Group.
Open Forum Infect Dis. 2019 May 3;6(6):ofz198.
Link

Cognitive function and drivers of cognitive impairment in a European and a Korean cohort of people living with HIV
De Francesco D, Jae-phil Choi, Jun Yong Choi, Rosan A. van Zoest, Jonathan Underwood, Judith Schouten, Nam Su Ku, Woo Joo Kim, Peter Reiss, Caroline A. Sabin and Alan Winston on behalf of the ComorBidity in Relation to AIDS (COBRA) Collaboration and the Korean NeuroAIDS Project.
Int J STD AIDS. 2019 Dec 4:956462419881080.
Link

2018

HIV-1 status is independently associated with decreased erectile function among middle-aged MSM in the era of combination antiretroviral therapy.
Dijkstra M, van Lunsen RHW, Kooij KW, Davidovich U, van Zoest RA, Wit FWMN, Prins M, Reiss P, Schim van der Loeff MF; AGEhIV Cohort Study Group.
AIDS. 2018; 32: 1137-1146.
Link

Clinical research cerebral MRI findings in HIV-positive subjects and appropriate controls.
Chhabra S, Underwood J, Cole JH, Caan M, Waldman A, Reiss P, Sabin CA, Sharp DJ, Winston A; CoBRA collaboration.
AIDS. 2018; 32: 2077-2081.
Link

The ‘COmorBidity in Relation to AIDS’ (COBRA) cohort: Design, methods and participant characteristics.
De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, Underwood J, van Zoest RA, Schouten J, Kooij KW, Prins M, Guaraldi G, Caan MWA, Burger D, Franceschi C, Libert C, Bürkle A, Reiss P; COmorBidity in Relation to AIDS (COBRA) collaboration.
PLoS One. 2018; 13: e0191791.
Link

No Evidence for Accelerated Aging-Related Brain Pathology in Treated Human Immunodeficiency Virus: Longitudinal Neuroimaging Results From the Comorbidity in Relation to AIDS (COBRA) Project.
Cole JH, Caan MWA, Underwood J, De Francesco D, van Zoest RA, Wit FWNM, Mutsaerts HJMM, Leech R, Geurtsen GJ, Portegies P, Majoie CBLM, Schim van der Loeff MF, Sabin CA, Reiss P, Winston A, Sharp DJ; Comorbidity in Relations to AIDS (COBRA) Collaboration.
Clin Infect Dis. 2018; 66: 1899-1909.
Link

Patterns of Co-occurring Comorbidities in People Living With HIV.
Francesco D, Verboeket SO, Underwood J, Bagkeris E, Wit FW, Mallon PWG, Winston A, Reiss P, Sabin CA; Pharmacokinetic and Clinical Observations in PeoPle Over fiftY (POPPY) study and the AGEhIV Cohort Study.
Open Forum Infect Dis. 2018 Oct 24;5(11):ofy272.
Link

2017

High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid.
Booiman T, Wit FW, Maurer I, De Francesco D, Sabin CA, Harskamp AM, Prins M, Garagnani P, Pirazzini C, Franceschi C, Fuchs D, Gisslén M, Winston A, Reiss P, Kootstra NA; Comorbidity in Relation to AIDS (COBRA) Collaboration.
Open Forum Infect Dis. 2017; 4: ofx108.
Link

Structural brain abnormalities in successfully treated HIV infection: associations with disease and cerebrospinal fluid biomarkers.
Van Zoest RA, Underwood J, De Francesco D, Sabin CA, Cole JH, Wit FW, Caan MWA, Kootstra NA, Fuchs D, Zetterberg H, Majoie CBLM, Portegies P, Winston A, Sharp DJ, Gisslén M, Reiss P; Co-morBidity in Relation to AIDS (COBRA) Collaboration.
J Infect Dis. 2017; 217: 69-81.
Link

Higher Prevalence and Faster Progression of Chronic Kidney Disease in Human Immunodeficiency Virus–Infected Middle-Aged Individuals Compared With Human Immunodeficiency Virus–Uninfected Controls.
Kooij KW, Vogt L, Wit FW, van der Valk M, van Zoest RA, Goorhuis A, Prins M, Post FA, Reiss P, on behalf of the AGEhIV Cohort Study.
J Infect Dis. 2017; 216: 622-631.
Link

Suboptimal primary and secondary cardiovascular disease prevention in HIV-positive individuals on antiretroviral therapy.
van Zoest RA, van der Valk M, Wit FW, Vaartjes I, Kooij KW, Hovius JW, Prins M, Reiss P; AGEhIV Cohort Study Group.
Eur J Prev Cardiol. 2017; 24: 1297-1307.
Link

Grey and white matter abnormalities in treated HIV-disease and their relationship to cognitive function.
Underwood J, Cole JH, Caan M, De Francesco D, Leech R, van Zoest RA, Su T, Geurtsen GJ, Schmand BA, Portegies P, Prins M, Wit FW, Sabin CA, Majoie C, Reiss P, Winston A, Sharp DJ; Co-morBidity in Relation to Aids (COBRA) Collaboration.
Clin Infect Dis. 2017; 65: 422-432.
Link

Increased brain-predicted aging in treated HIV disease.
Cole JH, Underwood J, Caan MW, De Francesco D, van Zoest RA, Leech R, Wit FW, Portegies P, Geurtsen GJ, Schmand BA, Schim van der Loeff MF, Franceschi C, Sabin CA, Majoie CB, Winston A, Reiss P, Sharp DJ; COBRA collaboration.
Neurology. 2017; 88: 1349-1357.
Link

Impact of comorbidity and aging on health-related quality of life in HIV-positive and HIV-negative individuals.
Langebeek N, Kooij KW, Wit FW, Stolte IG, Sprangers MAG, Reiss P, Nieuwkerk PT:  AGEhIV Study Group
AIDS. 2017; 31: 1471-1481.
Link

3D scattering transforms for disease classification in neuroimaging
T. Adel, T. Cohen, M. Caan, M. Welling; AGEhIV Study Group and the Alzheimer’s Disease Neuroimaging Initiative
Neuroimage Clin. 2017; 14: 506-17.
Link

Cerebral blood flow and cognitive function in HIV-infected men with sustained suppressed viremia on combination antiretroviral therapy
Tanja Su, HJ Mutsaerts, Matthan Caan, Ferdinand Wit, Judith Schouten, Gert Geurtsen, David Sharp, Maria Prins, Edo Richard, Peter Portegies, Peter Reiss, Charles Majoie, on behalf of the AGEhIV Cohort Study
AIDS. 2017; 31: 847-56.
Link

2016

Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals
Katherine Kooij, Ferdinand Wit, Thijs Booiman, Marc van der Valk, Maarten Schim van der Loeff, Neeltje Kootstra, Peter Reiss; AGEhIV Cohort Study Group.
J Infect Dis. 2016; 214: 1817-21.
Link

White matter structure alterations in HIV-1-infected men with sustained suppression of viraemia on treatment
Tanja Su, Matthan Caan, Ferdinand Wit, Judith Schouten, Gert Geurtsen, James Cole, David Sharp, Frans Vos, Maria Prins, Peter Portegies, Peter Reiss, Charles Majoie
AIDS. 2016; 30: 311-22.
Link

HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls
Katherine Kooij, Ferdinand Wit, Judith Schouten, Marc van der Valk, Mieke Godfried, Ineke Stolte, Maria Prins, Julian Falutz, Peter Reiss
AIDS, 2016; 30: 241-50.
Link

Determinants of reduced cognitive performance in HIV-1-infected middle-aged men on combination antiretroviral therapy.
Judith Schouten, Tanja Su, Ferdinand Wit, Neeltje Kootstra, Matthan Caan, Gert Geurtsen, Ben Schmand, Ineke Stolte, Maria Prins, Charles Majoie, Peter Portegies, Peter Reiss
AIDS, 2016; 30: 1027-38.
Link

Prevalence and determinants of insufficient work ability in older HIV-positive and HIV-negative workers.
Lisanne Moller, Ronald Brands, Judith Sluiter, Judith Schouten, Ferdinand Wit, Peter Reiss, Maria Prins, Ineke Stolte.
Int Arch Occup Environ Health, 2016; 89: 699-709.
Link

HIV-associated Neuroretinal Disorder in Patients with Well-suppressed HIV-infection: A Comparative Cohort Study.
Nazli Demirkaya, Ferdinand Wit, Thomas van den Berg, Katherine Kooij, Maria Prins, Reinier Schlingemann, Michael Abramoff, Peter Reiss, Frank Verbraak.
Invest Ophthalmol Vis Sci, 2016; 57: 1388-97.
Link

Difference in aortic stiffness between treated middle-aged HIV type 1-infected and uninfected individuals largely explained by traditional cardiovascular risk factors, with an additional contribution of prior advanced immunodeficiency.
Katherine Kooij*, Judith Schouten*, Ferdinand Wit, Marc van der Valk, Neeltje Kootstra, Ineke Stolte, Jan van der Meer, Maria Prins, Diederick Grobbee, Bert-Jan van den Born, Peter Reiss.
J Acquir Immune Defic Syndr. 2016; 73: 55-62.
Link

Liver fibrosis in HIV-infected individuals on long-term antiretroviral therapy: associated with immune activation, immunodeficiency and prior use of didanosine.
Katherine Kooij, Ferdinand Wit, Rosan van Zoest, Judith Schouten, Neeltje Kootstra, Michele van Vugt,
Maria Prins, Peter Reiss, Marc van der Valk.
AIDS. 2016; 30: 1771-80.
Link

Higher prevalence of hypertension in HIV-1-infected patients on combination antiretroviral therapy is associated with changes in body composition and prior stavudine exposure.
Rosan van Zoest, Ferdinand Wit, Katherine  Kooij, Marc van der Valk, Judith Schouten, Neeltje Kootstra, Joost Wiersinga, Maria Prins, Bert-Jan van den Born, Peter Reiss.
Clinical Infectious Diseases, 2016; 63: 205-13.
Link

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment.
Viviana Cobos Jiménez, Ferdinand Wit, Maaike Joerink, Irma Maurer, Agnes Harskamp, Judith Schouten, Maria Prins, van Leeuwen EM, Thijs Booiman, Steven Deeks, Peter Reiss, Neeltje Kootstra.
Journal of Infectious Diseases, 2016; 214: 216-25.
Link

White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on cART.
Tanja Su, Ferdinand Wit, Matthan Caan, Judith Schouten, Maria Prins, Gert Geurtsen, James Cole, David Sharp, Edo Richard, Liesbeth Reneman, Peter Portegies, Peter Reiss, Charles Majoie.
AIDS. 2016; 30: 2329-39.
Link

2015

Multivariate normative comparison, a novel method for more reliably detecting cognitive impairment in HIV infection.
Tanja Su, Judith Schouten, Gert Geurtsen, Ferdinand Wit, Ineke Stolte, Maria Prins, Peter Portegies, Matthan Caan, Peter Reiss, Charles Majoie, Ben Schmand; AGEhIV Cohort Study Group.
AIDS. 2015;29:547-57.
Link

Low bone mineral density in patients with well-suppressed HIV infection: association with body weight, smoking, and prior advanced HIV disease.
Katherine Kooij, Ferdinand Wit, Peter Bisschop, Judith Schouten, Ineke Stolte, Maria Prins, Marc van der Valk, Jan Prins, Berthe van Eck-Smit, Paul Lips, Peter Reiss; AGEhIV Cohort Study Group.
J Infect Dis. 2015; 211: 539-48.
Link

2014

Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study.
Judith Schouten, Ferdinand Wit, Ineke Stolte, Neeltje Kootstra, Marc van der Valk, Suzanne Geerlings, Maria Prins, Peter Reiss; AGEhIV Cohort Study Group.
Clin Infect Dis. 2014;59:1787-97.
Link

Data Sharing

We endeavour to make the data used in any AGEhIV Cohort Study manuscript publicly available, within the limits of the ethical governance under which the data were collected. To this end, we will share data directly with interested parties for two purposes: 1) verification and replication of an already published analysis derived from the AGEhIV Cohort Study, 2) novel scientific research projects using AGEhIV Cohort Study data.

To facilitate this, requests for data sharing can be made on a case-by-case basis following submission of a concept sheet. Once submitted the proposed research/analysis will undergo review by the AGEhIV Cohort Study team for evaluation of the scientific value, relevance to the study, design and feasibility, statistical power and overlap with existing projects. If the proposed analysis is for verification/replication, data will then be made available. If the proposed research is for novel science, upon completion of the review, feedback will be provided to the proposer(s). In some circumstances, a revision of the concept may be requested. If the concept is approved for implementation, a writing group will be established consisting of the proposers (up to 3 persons that were centrally involved in the development of the concept) and members of the AGEhIV Cohort Study group (or other appointed cohort representatives). All persons involved in the process of reviewing these research concepts are bound by confidentiality.

For more information about the procedure, data sharing or collaboration in general, please contact Ms. Lilly Dol (l.dol@aighd.org).

 
Amsterdam UMC-AMC
AIGHD
GGD Amsterdam
HIV monitoring
 
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